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If you are researching skin quality treatments, you have probably encountered three names: polynucleotides, Profhilo, and skin boosters. All three improve skin quality. So what is the difference?
As a practitioner who uses all three regularly, here is a clear, honest comparison.
The fundamentals
All three treatments share a common goal: improving the quality, health, and appearance of your skin without adding structural volume. But they achieve this through different mechanisms.
Skin boosters: deep hydration
Skin boosters deliver hyaluronic acid into the dermis to rehydrate from within. Primary mechanism: hydration.
Best for: dullness, dehydration, fine lines, lack of radiance.
Sessions: 2–3, spaced 3–4 weeks apart. Results 6–9 months. From £250 per session.
Profhilo: bio-remodelling
Profhilo uses concentrated hyaluronic acid that bio-remodels the skin's tissue. Stimulates collagen I, collagen III, elastin, and adipocytes.
Best for: skin laxity, loss of firmness, reduced elasticity.
Sessions: 2, spaced 4 weeks apart. Results 9–12 months. £450 per session.
Polynucleotides: cellular regeneration
Polynucleotide treatment uses purified DNA fragments that activate fibroblasts at a cellular level. Triggers genuine cellular repair and regeneration.
Best for: damaged, ageing, or biologically stressed skin, especially under-eye dark circles, sun damage, smoker's skin.
Sessions: 2–4, spaced 2–3 weeks apart. Results 6–12 months. From £250 per session.
How to choose
I assess each patient and recommend based on what their skin needs most. Often the best results come from combining treatments over time.
The key is that none of these treatments is universally "best". They are different tools designed for different problems.
→ Explore polynucleotides at DimAllure
→ Discover skin boosters at DimAllure
→ Learn more about Profhilo at DimAllure
→ Book your consultation
DimAllure
2 Wimpole Street, Marylebone, London
Personally administered by Dima Alomar, GPhC-registered Clinical Prescriber Pharmacist
Book your consultation →
Not sure which is right for you?
Book a consultation at DimAllure and Dima will assess your facial anatomy personally and recommend the right treatment for your goals.
Book Your Consultation — £50Can You Have Both?
Absolutely — and many patients at DimAllure do. Sculptra and fillers are highly complementary. A common approach is to use Sculptra to restore structural collagen across the temples, cheeks, and jawline, then use a small amount of filler for precise, targeted enhancement in areas like the lips or tear troughs.
Summary
- Timing: Fillers are immediate. Sculptra is gradual.
- Longevity: Sculptra lasts longer (up to 24 months).
- Reversibility: Fillers can be dissolved. Sculptra cannot.
- Mechanism: Fillers add volume. Sculptra rebuilds collagen.
- Best use: Fillers for specific areas. Sculptra for structural support.
At DimAllure, consultations are £50 and fully redeemable against your treatment — so there is no financial pressure and no obligation to proceed on the day.