Advanced cellular regeneration at our Wimpole Street clinic
Book Your ConsultationPolynucleotide therapy is one of the most advanced regenerative treatments available in aesthetics today. Derived from purified DNA fragments, polynucleotides work at a cellular level to repair, regenerate, and rejuvenate the skin, improving elasticity, tone, and resilience while supporting long-term skin health.
This is not a treatment that simply hydrates or fills. Polynucleotides fundamentally improve the biology of your skin, activating the cells responsible for producing collagen and elastin, improving blood flow and oxygenation, and reducing oxidative damage. The result is skin that looks and functions younger, not skin that has been masked or covered over.
At DimAllure, polynucleotide treatments are personally administered by Dima Alomar, a GPhC-registered Clinical Prescriber Pharmacist, at our clinic on Wimpole Street in Marylebone, London.
Polynucleotides are bio-stimulating molecules derived from purified DNA. When injected into the skin, they activate fibroblasts, the specialised cells responsible for producing collagen, elastin, and the extracellular matrix that gives skin its structure and resilience.
This activation triggers a cascade of regenerative processes within the skin. Cellular hydration increases at a deep level, far beyond what topical products can achieve. Collagen and elastin synthesis accelerates, improving firmness and elasticity. Blood flow and tissue oxygenation improve, bringing nutrients to the skin and supporting cellular repair. Oxidative stress and chronic low-grade inflammation are reduced, slowing the visible signs of ageing.
The net effect is genuine skin regeneration, not a temporary cosmetic improvement, but a lasting biological change in the quality and health of your skin tissue. This is why polynucleotides have become one of the most talked-about advances in regenerative aesthetics.
Polynucleotide therapy is exceptionally versatile and can be used across multiple areas where skin quality, resilience, and regeneration are needed.
This is where polynucleotide therapy has gained particular recognition. The skin beneath the eyes is extraordinarily thin and delicate, making it one of the most challenging areas to treat with conventional injectables. Polynucleotides are one of the few treatments that can safely and effectively improve dark circles, hollowing, fine crepey lines, and tired-looking under-eye skin. Many patients seek polynucleotide therapy specifically for this area.
Across the face, polynucleotides improve overall skin quality, texture, tone, and firmness. They are particularly effective for patients whose skin looks dull, tired, or has lost its natural vibrancy.
The neck is an area that ages visibly and responds poorly to topical treatments. Polynucleotides can improve laxity, texture, and crepiness in neck skin.
Sun damage, fine lines, and crepey skin across the chest benefit significantly from the regenerative effects of polynucleotide therapy.
Your polynucleotide journey begins with a thorough skin assessment and consultation at our Wimpole Street clinic. Dima will evaluate your skin’s current condition, discuss your specific concerns, review your medical history, and recommend a tailored treatment plan. This consultation is £50 and fully redeemable against treatment.
On treatment day, the treatment area is cleansed and a topical anaesthetic applied for comfort. Polynucleotides are then injected using fine needles or a cannula, depending on the area being treated. The choice of technique is based on the specific anatomy of the area and your individual needs. The entire procedure takes approximately 30–45 minutes.
After treatment, you may experience temporary redness, mild swelling, or small injection marks at the treatment sites. This is normal and typically resolves within 24–48 hours. There is no significant downtime, and most patients return to their normal activities the same day.
Results from polynucleotide therapy are not instant. Improvements develop gradually over the following weeks as your skin cells regenerate and produce new collagen and elastin. Most patients require 2–4 sessions, spaced 2–3 weeks apart, to achieve optimal results. The full effect of a completed course typically lasts 6–12 months.
Polynucleotide therapy is suitable for all skin types and is ideal for patients who want to improve their skin’s health and quality at a fundamental, cellular level. You may be a particularly good candidate if you are experiencing:
Polynucleotides also combine exceptionally well with other DimAllure treatments. Many patients choose to pair polynucleotide therapy with skin boosters for hydration and radiance, or with Sculptra for structural collagen stimulation, creating a comprehensive regenerative plan that addresses skin quality and facial support simultaneously.
2 Wimpole Street, Marylebone, London. Personally administered by a GPhC-registered prescriber.
Book Your ConsultationPolynucleotides are purified DNA fragments that, when injected into the skin, stimulate fibroblast activity and promote cellular repair and regeneration. They improve skin quality, elasticity, tone, and resilience at a deep, biological level, going beyond simple hydration.
Skin boosters primarily hydrate the skin using hyaluronic acid. Polynucleotides go further by activating fibroblasts, the cells that produce collagen and elastin, and promoting genuine cellular regeneration. They repair and rebuild the skin rather than simply hydrating it.
Yes. Polynucleotide therapy is one of the most effective injectable treatments for under-eye concerns including dark circles, hollowing, fine lines, and crepey skin. The under-eye area is thin and delicate, making it particularly responsive to the regenerative effects of polynucleotides.
Most patients benefit from 2 to 4 sessions spaced 2 to 3 weeks apart. Dima will recommend the right number of sessions based on your skin condition and goals during your consultation.
A topical anaesthetic is applied before treatment to minimise discomfort. Most patients describe the sensation as mild and very manageable, similar to other injectable treatments.
Results typically last 6 to 12 months, depending on your skin condition, lifestyle factors, and the number of sessions completed. Many patients choose maintenance sessions once or twice a year.
Anyone with tired, sun-damaged, ageing, or environmentally stressed skin who wants to improve skin quality at a cellular level. Polynucleotides are suitable for all skin types and are particularly effective for under-eye concerns, neck laxity, and peri-menopausal skin changes.
At DimAllure, polynucleotide therapy starts from £250 per syringe for under-eyes and £300 per syringe for face and neck. A 10% discount is available on subsequent sessions when booked together.